HUMAN  IMMUNODEFICIENCY  VIRUS &  AIDS

The epidemiological relationship between HIV & AIDS is only casual.

HIV ISOLATION

Direct isolation & purification of the so called HIV virus from the blood plasma from an AIDS pt or from an HIV +ve individual has never been reported.

All electron microscopic evidence has originated from highly complex mixed cell culture system s & never directly from patients.Never obtained as in other viral infections , by direct ultrafiltration of the periferal blood – in viremia – followed by ultracentrifugation  for sedimenting the viral particles , ultrasection & observation under EM.

In sucrose density gradients,which is the methodology for identification of EM monitored viral particles , [isolated as above ] like in case of of retroviruses, a sedimntation gradient of 1.16 gm/ ml is used for identification.

A] Many microvesicles & cellular debris also sediment at  this density.Hence strict EM monitoring is absolutely necessary.

B] This control is omitted in isolation of HIV virus.

C] the reverse transcriptase activity claimed as that of viral enzyme, EM controls were omitted , & this enzyme activity could be that ofcellular non viral origin.

To date publications of EM pictures of HIV donot satisfy the morphological features reqd for diagnosis of retroviral particles – dia of 100-120 nM  AND a surface studded with knobs.

The PCR METHODOLOGY USED TO QUANTIFY THE VIRAL LOAD in aids

PCR itself is not a scientifically acceptable technology to measure viral load as is well known.

Even when PCR shows high viral load EM has never correlated by demonstation of the HIV particle from the plasma.

DUBIOUS DEFINITION.

AIDS is defined as the presence of one or more AIDS defining illnesses with or without evidence of HIV infection. TB with HIV is AIDS , but TB without  HIV remains TB. Many diseases are AIDS , even without HIV +ve status.

AIDS defining illness = 30 in all , any disease may be present without immunodeficiency , eg Kaposis sarcoma , dementia & weight loss may occur without immunodeficiency.

HIV virus , even if existent  does not satisfy Kochs postulates nor Bradford – Hill criteria for proving itself as the to causing AIDS.

BEING HIV +VE DOES NOT MEAN THAT THE INDIVIDUAL HAS HIV INFECTION

BOTH ELISA & WESTERN BLOT TESTS ARE NON SPECIFIC. 70 DIFFERENT COMMON CLINICAL CONDITIONS CAUSE FALSE POSITIVE HIV TEST.

Documented common Examples –

hepatitis , vaccination, leprosy , TB , renal failure, influenza , tetanus vaccination , URTI , pregnancy , malaria , circulating immune complexes , RA , SLE , CT disease , CA , lymphoma , multiple bld transfusions , bilirubinemia , MS , Anti sperm antibodies – as in anal intercourse , EB virus , HLA antibodies , anti mitochondrial , microsomal , & smooth muscle antibodies , etc.

IMMUNODEFICIENCY & OPPORTUNISTIC INFECTIONS

IMMUNODEFICIENCY IS A DEVIATION OF SOME PARAMETERS OF IMMUNE SYSTEM FROM THE NORMAL STATE.

Immunodeficiency  doesnot necessarily lead to decreases in immunity , as this refers only to acquired immunity. OI occur mainly by nonspecific immune mechs.Failure of these mech is the actual cause of AIDS.

Stress syndrome has T immunodeficiency as a feature.

Severe OI & T defi  both have common causal factors – cytotoxics , etc

Severe OI causes stress syndrome & hence T defi

Stress causes catabolic states which suppresses the flora as well as causes T defi to cause OI

AZT

AZT used to treat AIDS –an immunodeficiency disease , itself is an immunosupressant , so how  is its   use justified.

AZT  Is immunotoxic & can generate AIDS – it can cause any of the 30 AIDS defining illnesses.

It is a lifelong therapy & kills Viral & human DNA.

The consequence of AZT therapy is death ,so deaths whether caused by AIDS or AZT is questionable.

OHCM states all anti HIV  Rx is experimental , so the best question to ask is not which is the best treatment for my patient , but which is the most appropriate clinical trial to enter my patient into?

according to trials , at the end of 12 yrs only 40% of  HIV +ve patients died &  20 % (survivors) had AIDS , remaining 40 % were healthy .

HENCE IT CAN BE INFERRED THAT AIDS IS NEITHER CONTAGIOUS NOR SEXUALLY TRANSMITTED.

IT IS A TOXIC – NUTRITIONAL SYNDROME CAUSED BY IMMUNOLOGICAL STRESSOR AGENTS says

Dr Roberto Giraldo , Independent researcher , Clinical Immunology , New York Hospital Cornell Medical Center.

References:

INTERNATIONAL CONFERENCE ON VALIDITY OF HIV / AIDS PROGRAMME , Academy of Nutrition improvement , Nagpur.-30 Jan 2000 in coop with ministry of Health , Govt of India.