CANCER (MALIGNANCY) ie CA

CA GENOME

It is believed that smoking causes Lung Cancer.  Why then all lung cancer patients are not smokers? Why is it that all smokers do not develop cancer?  Do we not question whether cancer is caused by carcinogens or because of DNA changes? Despite the noble prize winning discovery that cancer is due to cellular genetic events? The body has suppressed genes, which normally suppresses cell proliferation and prevent cancer from occurring.Thus CA could be predetermined.

CANCER PRONENESS

CA occurs in the senile cell , which have reduced FCDC ,Finite cell div capacity , so when it divides in its last few multiplications , there  is a  proneness  to chromosomal aberrations ,causing activation of cancer oncogenes , if there is a [ predetermined ] CA genome. Hence Cytotoxic agents can prepone a predetermined late cancer.

CARCINOGEN

 No carcinogen has yet proved to be the cause of any particular cancer , in humans or in animals , in vitro or in vivo. Also everything under the sun including the sun itself has been considered as carcinogenic. The individual is left with no choice for e.g. nulliparity increases the risk of CA Breast & Endometrium whereas parity increases the risk of CA cervix

EARLY DIAGNOSIS

The microscope cannot detect cancer or precancer bcos there is no distinctive cellular feature of the Ca cell, Cytological research has revealed that the Ca cell is not a distinctive structural entity.The Ca cell may be defined as one that has proved itself by behaving as such.The microscopic judgements often fail when ‘ cancerous’tissues behave non cancerous & vice cersa. Cell & nuclear size & shape, cellular arrangements are diagnostic of any rapidly dividing cell population & not cancer specific.

 METASTASIS 

We believe that if not treated early, cancer spreads from one site to another (Metastasis).  How do people operated for early Cancer then develop metastasis?  When Cancer becomes diagnosable, it is many million cells strong & quite a few years old. A CA cell may lie dormant without behaving in a malignant manner for many years- the correct diagnosis in such cases is a “ lump “ in the breast or elsewhere & not CA.

THERAPY

SURGERY

 intervention may ppte distant spread , even in Breast CA stage 1. Cancer per say doesn’t cause any troublesome symptoms except by mode of obstruction which may have to be surgically relieved.

CHEMOTHERAPY

 During complete remission of leukemia, induced by so called “curative chemotherapy” , 100 to 1000 million leukemic cells still remain , making relapse inevitable. Remissions can also be spontaneous in nature.

RADIOTHERAPY-& CHEMO THERAPY

These destroy many cell populations which divide faster than many a cancer , resulting in hair falling off, ulceration of skin , mouth & intestine , BM depression causing anemia & making the patient defenseless against infection.   Therefore on basis of the presence of a few CA cells on biopsy coexisting harmoniously with its owner , if  premature treatment is undertaken ( eg leukemia ) , this might ppte an active leukemic stage by causing cellular death of dividing cells & in the process causing premature ageing of cells & activating the CA genome.

MORTALITY

 in malignancy is usually due to cardiovascular disease.  Thus patients usually die with the CA than by it..

 [ref s–NATURE of Cancer – by MLKothari & Lopa Mehta ]